Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7548212

Reference Type

Journal Article

Title

Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction

Author(s)

Krausser, M; Hummel, W; Groger, H

Year

2007

Is Peer Reviewed?

Yes

Journal

European Journal of Organic Chemistry
ISSN: 1434-193X
EISSN: 1099-0690

Publisher

WILEY-V C H VERLAG GMBH

Location

WEINHEIM

Volume

2007

Issue

Page Numbers

5175-5179

DOI

10.1002/ejoc.200700647

Web of Science Id

WOS:000250731300003

URL

http://://WOS:000250731300003
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Abstract

A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantio selectivities of >99 % ee. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).