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HERO ID
7548212
Reference Type
Journal Article
Title
Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction
Author(s)
Krausser, M; Hummel, W; Groger, H
Year
2007
Is Peer Reviewed?
Yes
Journal
European Journal of Organic Chemistry
ISSN:
1434-193X
EISSN:
1099-0690
Publisher
WILEY-V C H VERLAG GMBH
Location
WEINHEIM
Volume
2007
Issue
31
Page Numbers
5175-5179
DOI
10.1002/ejoc.200700647
Web of Science Id
WOS:000250731300003
URL
http://
://WOS:000250731300003
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Abstract
A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantio selectivities of >99 % ee. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).
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