US EPA

7550046 

Journal Article 

Case Report 

Idiopathic glomerular capillary endotheliosis in a male patient with nephrotic syndrome: Response to combination therapy with prednisone and nitrogen mustard 

Fu, QY; Zhou, ZL; Zhang, ZH 

2014 

1 

Kuwait Medical Journal
ISSN: 1607-8047 

46 

2 

155-159 

English 

WOS:000335383700014 

Nephrotic syndrome (NS) in patients with glomerular capillary endotheliosis is rare; most of the few reported cases have had preeclampsia. We present an interesting case of idiopathic glomerular capillary endotheliosis in a male patient with NS. A renal biopsy showed capillary endothelial swelling, occlusion of capillary loops, fusion of epithelial cell foot processes, no electron-dense deposits, and no tubulointerstitial and arteriolar changes. We administered a novel combination therapy with prednisone and nitrogen mustard to combat the endothelial dysfunction. The systemic symptoms and proteinuria gradually disappeared. This case is the first instance of successful treatment with prednisone plus nitrogen mustard in idiopathic glomerular capillary endotheliosis, and also provides evidence for the superiority of prednisone and nitrogen mustard-based regimens over prednisone alone.