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7556542 
Journal Article 
DEVELOPMENT AND VALIDATION OF A NEW CAPILLARY ZONE ELECTROPHORESIS METHOD FOR THE ASSAY OF ONDANSETRON 
Arama, C; Varvara, A; Monciu, CM; , 
2011 
Farmacia
ISSN: 0014-8237 
SOC STINTE FARMACEUTICE ROMANIA 
BUCURESTI 
34-43 
WOS:000287782700004 
An effective new capillary zone electrophoresis (CZE) assay has been developed for the determination of ondansetron hydrochloride and one of its impurities, ((3RS)-3-[(dimethylamino)methyl]-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) noted impurity A. Best resolution between the two analytes was achieved using a 35 mM phosphate buffer (pH 6.0) as running electrolyte, 20 kV applied voltage at 15 C, with direct UV detection at 216 nm; the migration times were 3.05 minutes and 3.3 minutes, respectively. The newly established method was validated with respect to linearity, precision, accuracy, selectivity, detection and quantitation limits.The proposed CZE method is simple, fast and reliable, with convenient results in the assay of ondansetron and its impurity in pharmaceutical dosage forms (injectable solutions).