Health & Environmental Research Online (HERO)


Print Feedback Export to File
7559703 
Journal Article 
Synthesis and biological activity of pyrazino[3,2,1-j,k]carbazoles 
Shanmugasundaram, K; Prasad, KJR; , 
1998 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
NATL INST SCIENCE COMMUNICATION 
NEW DELHI 
37 
11 
1133-1136 
English 
WOS:000078290000011 
1-Oxo-1,2,3.4-tetrahydrocarbazole derivatives 1a-d have been reacted with ethanolamine to yield the respective ketimines 2a-d which on reduction with sodium borohydride furnish the corresponding amino derivatives 3a-d. The pyrazino[3,2,1-j,k]carbazole derivatives 4a-d are obtained by the cyclisation of 3a-d using ammonium chloride in diphenyl ether. Compounds 4a-d have been tested for their antimicrobial activity using chloramphenicol as a reference compound.