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HERO ID
7560621
Reference Type
Journal Article
Title
Anilines Made Easily: From Aldehydes to Tri-, Tetra-, and Pentasubstituted Anilines in Two Steps
Author(s)
Neumann, H; Jacobi von Wangelin, A; Klaus, S; Strübing, D; Gördes, D; Beller, M; ,
Year
2003
Is Peer Reviewed?
Yes
Journal
Angewandte Chemie (International Edition)
ISSN:
1433-7851
EISSN:
1521-3773
Publisher
WILEY-V C H VERLAG GMBH
Location
WEINHEIM
Volume
42
Issue
37
Page Numbers
4503-4507
Language
English
PMID
14520750
DOI
10.1002/anie.200351484
Web of Science Id
WOS:000185841400014
URL
http://doi.wiley.com/10.1002/anie.200351484
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Abstract
Easy as one, two, three. Highly substituted anilines are accessible with unprecedented efficiency from the three-component-coupling reaction of O-benzyl carbamate, aldehydes, and dienophiles followed by a new domino aromatization/deprotection reaction involving transfer hydrogenation (see scheme). EWG: electron-withdrawing group.
Keywords
Anilines; Multicomponent reactions; Palladium; Transfer hydrogenation; Aldehydes; Amines; Aromatization; Hydrogenation; Reaction kinetics; Synthesis (chemical); Transfer hydrogenation; Aromatic compounds; aldehyde; aniline derivative; carbamic acid derivative; o benzyl carbamate; unclassified drug; aromatization; article; chemical reaction; chemical structure; deprotection reaction; electron; hydrogenation; reaction analysis; structure analysis; synthesis; three component coupling reaction
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