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7569277 
Journal Article 
Synthesis of 1-amino-2-methylindoline by Raschig process: Parallel reactions, modeling, and optimization 
Elkhatib, M; Peyrot, L; Metz, R; Tenu, R; Elomar, F; Delalu, H 
2002 
Yes 
International Journal of Chemical Kinetics
ISSN: 0538-8066
EISSN: 1097-4601 
34 
10 
575-584 
WOS:000178179200002 
The reaction between chloramine and 2-methylindoline was studied at pH 12.89, T = 40degreesC, and for different initial concentrations of reactants. The interaction includes two concurrent bimolecular mechanisms leading to 1-amino-2-methylindoline and 2-methylindole The rate laws were determined at the first moments of the reaction by using a differential method. By considering the totality of the reactions that occur in the medium, an appropriate mathematical model was developed. It permits to follow the evolution of the system over time and to calculate the final yields of reaction products An optimization in terms of the initial contents of 2-methylindoline and chloramine was performed It indicated that the maximum yield of 1-amino-2-methylindoline does not exceed 56%. The results show the limit of the Raschig process for the synthesis of indolic hydrazines in aqueous medium. (C) 2002 Wiley Periodicals, Inc.