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HERO ID
7570781
Reference Type
Journal Article
Title
HPLC with mass spectrometry detection for the analysis of endocrine disruptors
Author(s)
Krol, J; Block, E; Young, M; Benvenuti, M; Yonekubo, J; Romano, J
Year
2000
Journal
Preprints of Papers, Presented at the National Meeting - American Chemical Society, Division of Environmental Chemistry
ISSN:
0093-3066
Location
San Francisco, CA
Volume
40
Issue
1
Page Numbers
93-96
Language
English
Abstract
High Performance Liquid Chromatography (HPLC) can be utilized to separate the various endocrine disruptors, and if UV active, they can be identified and quantitated. But the diversity of chemical properties and sample matrices often compromises accurate identification and quantitation using only UV absorbance detection. Combined with HPLC, mass spectrometry (MS) offers qualitative confirmation and quantitation. Examples are bisphenol A and phthalates leached from plastics, nonylphenol from non-ionic surfactant degradation, and carbamate pesticide residues. These endocrine disruptors are found in the ppt (ng/L) concentrations in drinking water, and their enrichment is integral to their analysis. Solid phase enrichment procedures are utilized to concentrate the analytes into ppb concentrations necessary for LC/UV/MS analysis.
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