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HERO ID
7584615
Reference Type
Journal Article
Title
An efficient conversion of carboxylic acids into Weinreb amides
Author(s)
Katritzky, AR; Yang, H; Zhang, S; Wang, M
Year
2002
Volume
2002
Issue
11
Page Numbers
39-44
Language
English
Abstract
Efficient conversions of carboxylic acids into Weinreb amides were achieved by treatment of N-acylbenzotriazoles 2a-i with N,O-dimethylhydroxylamine hydrochloride under mild conditions. No racemization was found when optically active acids were employed.
Keywords
amide; benzotriazole derivative; carbamic acid derivative; carboxylic acid derivative; hydroxylamine; n methoxy 4,n dimethylbenzamide; n methoxy n methyl 2 thiophenecarboxamide; n methoxy n methyl 2,2 diphenylacetamide; n methoxy n methyl 3 phenyl 2 propenamide; n methoxy n methylbenzamide; n methoxy n methylisonicotinamide; n methoxy n methylproprionamide; n,o dimethylhydroxylamine; tert butyl n [1 (methoxymethylamino)carbonyl 2 methylpropyl]carbamate; tert butyl n [2 (methoxymethylamino) 1 methyl 2 oxoethyl]carbamate; unclassified drug; article; chemical reaction; chemical structure; optical rotation; racemization
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