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7597452 
Journal Article 
Ob aktivatsii baǐgonom (2-izopropoksifenil-N-metil karbamat) fermentativnogo dezaminirovaniia 2-fenil-étilamina 
ZeçNalov, TA 
1985 
1 
Voprosy Meditsinskoĭ Khimii
ISSN: 0042-8809 
31 
5 
60-64 
Russian 
Carbamate-containing pesticides, particularly baygon, might alter the activity of monoamine oxidase (MAO) in vivo. Baygon was found to stimulate selectively the deamination of 2-phenylethylamine, which is a specific substrate of MAO of the B type; the stimulating effect of baygon was reversible. Kinetic studies showed that the stimulation of the enzyme in presence of baygon of the competitive type. A selective inhibitor of MAO of the B type deprenyl might prevent the impairments of the central nervous system, which are observed in the baygon intoxication. Estimation of the MAO activity in blood thrombocytes may be used as a new biochemical test in diagnosis of intoxications caused by pesticides. 
amine oxidase (flavin containing); monoamine oxidase inhibitor; phenethylamine; phenethylamine derivative; propoxur; serotonin; tyramine; animal; article; brain; deamination; drug effect; enzyme activation; enzyme specificity; enzymology; intracellular membrane; liver mitochondrion; male; metabolism; mitochondrion; rat; rat strain; Animal; Brain; Deamination; English Abstract; Enzyme Activation; Intracellular Membranes; Male; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Propoxur; Rats; Rats, Inbred Strains; Serotonin; Substrate Specificity; Tyramine 
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