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7612982 
Journal Article 
Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism 
Wahlang, B; Falkner, KC; Cave, MC; Prough, RA; , 
2015 
Yes 
Advances in Pharmacology
ISSN: 1054-3589 
Academic Press Inc. 
74 
1-33 
English 
26233902 
The purpose of this chapter is to provide insight into which human cytochromes P450 (CYPs) may be involved in metabolism of chemical carcinogens and anticancer drugs. A historical overview of this field and the development of literature using relevant animal models and expressed human CYPs have provided information about which specific CYPs may be involved in carcinogen metabolism. Definition of the biochemical properties of CYP activity came from several groups who studied the reaction stoichiometry of butter yellow and benzo[α]pyrene, including their role in induction of these enzyme systems. This chapter will list as much as is known about the human CYPs involved in carcinogen and anticancer drug metabolism, as well as summarize studies with rodent CYPs. A review of three major classes of anticancer drugs and their metabolism in humans is covered for cyclophosphamide, procarbazine, and anthracycline antibiotics, cancer chemotherapeutic compounds extensively metabolized by CYPs. The emerging information about human CYP gene polymorphisms as well as other enzymes involved in foreign compound metabolism provides considerable information about how these genetic variants affect carcinogen and anticancer drug metabolism. With information available from individual's genomic sequences, consideration of populations who may be at risk due to environmental exposure to carcinogens or how to optimize their cancer therapy regimens to enhance efficacy of the anticancer drugs appears to be an important field of study to benefit individuals in the future. 
Anthracycline antibiotics; Carcinogen metabolism; Cyclophosphamide; Cytochrome P450; Gene expression; Gene polymorphism; Nuclear receptors; Procarbazine; Reactive chemical intermediates 
Hardwick J.P.