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7636020 
Journal Article 
Ditopic crown ether-guanidinium ion receptors for the molecular recognition of amino acids and small peptides 
Spaeth, A; Koenig, B; , 
2010 
1 
Tetrahedron
ISSN: 0040-4020 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
66 
10 
1859-1873 
English 
WOS:000275260400012 
A series of ditopic synthetic receptors based on a crown ether-guanidinium ion recognition motif is reported. The compounds show binding affinity to selected amino acids, including important neuro-transmitters. The effect of the distance of the ammonium and the carboxylate ion, the rigidity of the spacer, and the use of pre-organized pyrrole- and pyrene-guanidinium groups on binding affinity and selectivity are discussed. (C) 2010 Elsevier Ltd. All rights reserved.