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7663546 
Journal Article 
A new approach to the synthesis of aristolactams. Total synthesis of cepharanone A and B 
Couture, A; Deniau, E; Grandclaudon, P; Lebrun, S; , 
1997 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
GEORG THIEME VERLAG 
STUTTGART 
12 
1475-1477 
English 
WOS:000071627400052 
An efficient, concise and tactically new synthesis of aristolactams is described. The key step is the aryne-mediated cyclization of an amino carbanion derived from a phosphorylated halobenzamide derivative. Horner reaction, radical cyclization and ultimate deprotection complete the synthesis of the phenanthrene lactam alkaloids. The viability of the strategy is further illustrated by the synthesis of cepharanone A and B.