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HERO ID
7663546
Reference Type
Journal Article
Title
A new approach to the synthesis of aristolactams. Total synthesis of cepharanone A and B
Author(s)
Couture, A; Deniau, E; Grandclaudon, P; Lebrun, S; ,
Year
1997
Is Peer Reviewed?
1
Journal
Synlett
ISSN:
0936-5214
EISSN:
1437-2096
Publisher
GEORG THIEME VERLAG
Location
STUTTGART
Issue
12
Page Numbers
1475-1477
Language
English
DOI
10.1055/s-1997-1046
Web of Science Id
WOS:000071627400052
Abstract
An efficient, concise and tactically new synthesis of aristolactams is described. The key step is the aryne-mediated cyclization of an amino carbanion derived from a phosphorylated halobenzamide derivative. Horner reaction, radical cyclization and ultimate deprotection complete the synthesis of the phenanthrene lactam alkaloids. The viability of the strategy is further illustrated by the synthesis of cepharanone A and B.
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