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7665286 
Journal Article 
Synthesis and Antiviral Activities of Phenanthroindolizidine Alkaloids and Their Derivatives 
Wang, K; Su, Bo; Wang, Z; Wu, M; Li, Z; Hu, Y; Fan, Z; Mi, Na; Wang, Q; , 
2010 
Yes 
Journal of Agricultural and Food Chemistry
ISSN: 0021-8561
EISSN: 1520-5118 
AMER CHEMICAL SOC 
WASHINGTON 
2703-2709 
20000413 
WOS:000275087600014 
Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine, and optically pure alkaloids S-(+)-tylophorine and R-(-)-tylophorine were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization modifications based on tylophorine increased stability and water solubility and improved the antiviral activity in application. The bioassay results showed that most of these synthesized compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial Ningnanmycin. Especially, tylophorine salt derivatives 10, 11, 13, 17, and 22 emerged as potential inhibitors of plant virus. These findings demonstrate that these phenanthroindolizidine alkaloids and their salt derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.