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7666119 
Journal Article 
Five new phenolic compounds from Dendrobium aphyllum 
Yang, D; Liu, LY; Cheng, ZQ; Xu, FQ; Fan, WW; Zi, CT; Dong, FW; Zhou, J; Ding, ZT; Hu, JM; , 
2015 
Yes 
Fitoterapia
ISSN: 0367-326X 
ELSEVIER SCIENCE BV 
AMSTERDAM 
100 
11-18 
English 
25447160 
WOS:000349881300003 
One new phenanthrene, aphyllone A (1) and four new bibenzyl derivatives, aphyllone B (2) and aphyllals C-D (3-5), together with nine known compounds (6-14), were isolated from the stems of Dendrobium aphyllum (Roxb.) C. E. Fischer. The structures of these new compounds were elucidated by means of extensive spectroscopic analyses, and the absolute configuration of compound 1 was determined by single crystal X-ray diffraction and quantum calculations. Compounds 6, 8 and 14 inhibited NO production at the concentration of 25 μM in LPS-stimulated RAW264.7 cells with the inhibition (%) of 32.48, 35.68, and 38.50. Compound 2 possessed significant DPPH radical scavenging activity with scavenging percentage of 87.97% at the concentration of 100 μg/mL. 
Bibenzyl derivative; Dendrobium aphyllum; NO production; Phenanthrene