5 alpha-reductase inhibitors and anti-prostate cancer activities of some synthesized 4 '-(aryl)-4-pregneno[3,2-e]pyridinone derivatives | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7666540

Reference Type

Journal Article

Title

5 alpha-reductase inhibitors and anti-prostate cancer activities of some synthesized 4 '-(aryl)-4-pregneno[3,2-e]pyridinone derivatives

Author(s)

Amr, AbdElGE; Abdalla, MM; Hussein, MMM; Safwat, HM; Elgamal, MH; ,

Year

2017

Is Peer Reviewed?

Journal

Biomedical Research
ISSN: 0970-938X
EISSN: 0976-1683

Publisher

ALLIED ACAD

Location

LONDON

Page Numbers

601-607

Web of Science Id

WOS:000393490700019

Abstract

A series of 2 '-mercapto-3 '-cyano-4 '-(aryl)-4-pregneno-[3,2-e] pyridine-20-ones (3a-h) and 1 '-thiocarbamoyl-2 '-amino-4 '-(aryl)-4-pregneno-[3,2-e] pyridine-20-one derivatives (4a-h) were synthesized using progesterone 1 "17-acetyl-1,7,8,10,11,12,13,15,16,17-decahydro-10,13-dimethyl-2Hcyclopenta[a]phenanthren-3(6H,9H,14H)-one" as starting material. The synthesized compounds were evaluated for 5 alpha-reductase inhibitors and anti-prostate cancer activities compared to Anastrozole (R) as positive control. Some of the tested compounds exhibited better activities than Anastrozole (R). Compounds 3a-h and 4a-h showed potent 5a-reductase inhibitors and anti-prostate cancer activities than Anastrozole (R)