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7667470 
Journal Article 
"One-Pot" Technique for Transformation of the Aporphine Alkaloid Boldine into Phenanthrene Seco-Boldine with Subcritical Water 
Lekar', AV; Maksimenko, EV; Borisenko, SN; Khizrieva, SS; Borisenko, NI; Minkin, VI; , 
2020 
1 
Russian Journal of Physical Chemistry B, Focus on Physics
ISSN: 1990-7931
EISSN: 1990-7923 
MAIK NAUKA/INTERPERIODICA/SPRINGER 
NEW YORK 
14 
7 
1153-1157 
English 
WOS:000611892900013 
A "one-pot" method for the production of phenanthrene seco-boldine from the aporphine alkaloid boldine in subcritical water was developed and studied. The efficiency of the method for the preparation of seco-boldine in subcritical water was studied at temperatures from 100 to 230 degrees C. The "one-pot" technique in subcritical water allows a quantitative yield of seco-boldine in one step without using any catalytic additives. The structure of the product was confirmed by NMR and ESI-MS. The proposed technique does not require the use of expensive and toxic organic solvents. The preparation of seco-boldine by this technique takes 30 min, which makes it possible to develop an inexpensive, environmentally safe procedure for the production of seco-boldine in subcritical water. 
aporphine alkaloids; boldine; HPLC; Keywords: one-pot; NMR; phenanthrene alkaloids; seco-boldine; subcritical water