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7669608 
Journal Article 
The role of adenosine A2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons 
Mori, A; Shindou, T; Ichimura, M; Nonaka, H; Kase, H 
1996 
Yes 
Journal of Neuroscience
ISSN: 0270-6474
EISSN: 1529-2401 
Society for Neuroscience 
16 
2 
605-611 
English 
8551344 
WOS:A1996TP51900018 
We demonstrated an adenosine A2a receptor-mediated disinhibition of medium spiny projection neurons using intracellular recording and the whole-cell patch-clamp recording applied to these cells, visually identified in thin rat striatal slices. The A2a receptor agonist 2-[p-(2-carboxyethyl) phenylethylamino]-5'-N- ethylcarboxamido adenosine (CGS-21680; 0.3-10 microM) suppressed GABAergic synaptic transmission onto these cells in a manner inhibited by the A2a receptor-selective antagonist (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (0.1-1.0 microM). The A1 receptor antagonists had no effect on the CGS-21680-induced suppression. Analysis of spontaneous miniature inhibitory synaptic currents indicated that suppression of intrastriatal GABAergic synaptic transmission was attributable to presynaptic, but not postsynaptic, A2a receptors. Therefore, the A2a receptor may regulate striatal output activity by relieving GABA-mediated inhibition of the medium spiny projection neurons, which explains the ability of purinergic agents to affect motor control. 
adenosine; adenosine receptor; GABA; striatum; CGS-21680; KF17837; IPSP; IPSC; cAMP