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7671892 
Journal Article 
Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae 
Osorio, E; Arango, GJ; Jiménez, N; Alzate, F; Ruiz, G; Gutiérrez, D; Paco, MA; Giménez, A; Robledo, S 
2007 
Yes 
Journal of Ethnopharmacology
ISSN: 0378-8741 
111 
3 
630-635 
English 
17296281 
WOS:000246716300029 
Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25 microg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS=10 and 16, respectively). The extracts from Desmopsis panamensis, Pseudomalmea boyacana, Rollinia exsucca and Rollinia pittieri showed good antiplasmodial activity (IC50 < 10 microg/ml). No correlation between antiplasmodial activity and inhibition of beta-hematin production was found. The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts. Results presented here also demonstrate which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas' disease and malaria. 
Annonaceae; Antiplasmodial activity; Colombian plants; Leishmanicidal activity; Trypanocidal activity