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7672227 
Journal Article 
A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study 
Robinson, A; Kumar, TV; Sreedhar, E; Naidu, VG; Krishna, SR; Babu, KS; Srinivas, PV; Rao, JM 
2008 
Yes 
Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405 
18 
14 
4015-4017 
English 
18579374 
WOS:000257640400042 
The dried roots of Saussurea lappa, called costus roots, are used in the traditional system of medicine for the treatment of cancer. In our investigation for the anticancer constituents from the hexane extract of this plant, a new sesquiterpene (1) was isolated along with the known compounds costunolide (2), beta-cyclocostunolide (3), dihydro costunolide (4) and dehydro costuslactone (5). Their structures were established by the extensive spectroscopic analyses. In addition, costunolide and beta-cyclocostunolide derivatives were synthesized using Michael-type addition reaction of NaOMe to the alpha-methylene-gamma-lactone moiety. All the compounds were tested for their in vitro cytotoxic activity. Compound 1 exhibited potent cytotoxic activity and other compounds displayed moderate activity. 
β-Cyclocostunolide; Anticancer activity; Costunolide; Costus roots; Saussurea lappa