Health & Environmental Research Online (HERO)


Print Feedback Export to File
7676166 
Journal Article 
Chemoselective Hydro(Chloro)pentafluorosulfanylation of Diazo Compounds with Pentafluorosulfanyl Chloride 
Qing, FL; Shou, JY; Xu, XH 
2021 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
John Wiley and Sons Inc 
English 
33928731 
Pentafluorosulfanyl chloride (SF 5 Cl) is the most prevalent reagent for the incorporation of SF 5 group into organic compounds. However, the preparation of SF 5 Cl often relied on hazardous reagents and specialized apparatuses. Herein we described a safe and practical synthesis of a bench-stable and easy-to-handle solution of SF 5 Cl in n -hexane under gas-reagent-free conditions. The synthetic application of SF 5 Cl was demonstrated through the unprecedented reaction with diazo compounds. The chemoselective hydro- and chloropentafluorosulfanylations of α-diazo carbonyl compounds were developed in the presence of K 3 PO 4 or copper catalyst respectively. These reactions provide a direct and efficient access to various α-pentafluorosulfanyl carbonyl compounds of high value for potential applications. 
copper; diazo compounds; pentafluorosulfanyl chloride; pentafluorosulfanylation; radical reactions