Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
7686084
Reference Type
Journal Article
Subtype
Review
Title
Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques
Author(s)
Li, Y; Yang, Y; Li, R; Tang, X; Guo, D; Qing, Y; Qin, Y; ,
Year
2019
Is Peer Reviewed?
Yes
Journal
International Journal of Nanomedicine
ISSN:
1176-9114
EISSN:
1178-2013
Publisher
DOVE MEDICAL PRESS LTD
Location
ALBANY
Volume
14
Page Numbers
7217-7236
Language
English
PMID
31564875
DOI
10.2147/IJN.S216175
Web of Science Id
WOS:000483720500002
URL
https://www.dovepress.com/enhanced-antibacterial-properties-of-orthopedic-implants-by-titanium-n-peer-reviewed-article-IJN
Exit
Abstract
Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.
Keywords
Antibacterial property; Drug delivery; Orthopaedic implant; Surface modification; Titanium dioxide nanotube
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity