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7695223 
Journal Article 
Synthesis of the chiral spiro-cyclopropane derivative and its crystal structure 
Zhang, XY; Chen, QH; , 
2000 
1 
Progress in Natural Science
ISSN: 1002-0071 
TAYLOR & FRANCIS LTD 
LONDON 
10 
11 
867-873 
English 
WOS:000090134900010 
The spiro[ 1-bromo-4-l-mentholoxy-5-oxo-6-oxabicyclo[3.1.0] hexane-2,3 '-(4 ' -ethoxy-5 ' -1-menthyloxybutyrolactone)] 4 was synthesized via the tandem double Michael addition/internal nucleophilic substitution of chiral synthon 1, 5-1-menthyloxy- 3-bromo-2 (SH)-furanone, with nucleophilic ethanol. The two synthetic routes to compound 4 and its analytical data of structure are reported. The absolute configuration of 4 was determined by X-ray crystallography. These results provide a valuable strategy for synthesizing some biologically active molecules. 
Biological activity; Spiro-cyclicpropane derivative containing multichiral centers; Tandem asymmetric reaction