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HERO ID
7699444
Reference Type
Journal Article
Title
Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats
Author(s)
Zhou, YH; Yu, JP; Liu, YF; Teng, XJ; Ming, M; Lv, P; An, P; Liu, SQ; Yu, HG
Year
2006
Is Peer Reviewed?
1
Journal
Mediators of Inflammation
ISSN:
0962-9351
EISSN:
1466-1861
Publisher
HINDAWI LTD
Location
LONDON
Volume
2006
Issue
5
Page Numbers
92642
Language
English
PMID
17392580
DOI
10.1155/MI/2006/92642
Web of Science Id
WOS:000242588500001
Abstract
Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic administration with 2,4,6-trinitrobenzene sulfonic acid (TNBS, 150 mg/kg). EGB in doses of (50, 100, 200 mg/kg) was administered for 4 weeks to protect colitis. The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF-alpha, NF-kappaBp65, and IL-6 in the colon tissues of experimental colitis in a dose-dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation.
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