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HERO ID
7700310
Reference Type
Journal Article
Title
Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms
Author(s)
Calil-Silveira, J; Serrano-Nascimento, C; Nunes, MT; ,
Year
2012
Is Peer Reviewed?
1
Journal
Molecular and Cellular Endocrinology
ISSN:
0303-7207
EISSN:
1872-8057
Publisher
ELSEVIER IRELAND LTD
Location
CLARE
Volume
350
Issue
1
Page Numbers
118-124
Language
English
PMID
22178794
DOI
10.1016/j.mce.2011.12.002
Web of Science Id
WOS:000301610000013
URL
https://linkinghub.elsevier.com/retrieve/pii/S0303720711007106
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Abstract
Iodine is a critical element involved in thyroid hormone synthesis. Its efflux into the follicular lumen is thought to occur, in part, through pendrin at the apical membrane of thyrocytes. This study attempted to investigate whether iodide administration affects SLC26A4 mRNA expression in rat thyroid and in PCCl3 cells. Rats and cells were treated or not with NaI from 30 min up to 48 h. One group was concomitantly treated with sodium perchlorate. SLC26A4 mRNA expression was also investigated in PCCl3 cells treated with actinomycin D prior to NaI treatment. Iodide administration significantly increased SLC26A4 mRNA content in both models. The simultaneous administration of NaI and perchlorate, as well as the treatment of PCCl3 cells with actinomycin D prevented this effect, indicating that intracellular iodide is essential for this event, which appears to be triggered by transcriptional mechanisms. These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression.
Keywords
Escape phenomenon; Pendrin; Perchlorate; SLC26A4; Wolff-Chaikoff effect
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