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7701886 
Journal Article 
The potential protective role of caveolin-1 in intestinal inflammation in TNBS-induced murine colitis 
Weiss, CR; Guan, Q; Ma, Y; Qing, G; Bernstein, CN; Warrington, RJ; Peng, Z; , 
2015 
1 
PLoS ONE
EISSN: 1932-6203 
PUBLIC LIBRARY SCIENCE 
SAN FRANCISCO 
e0119004 
English 
25756273 
WOS:000351275700035 
Caveolin-1 (Cav-1) is a multifunctional scaffolding protein serving as a platform for the cell's signal-transduction and playing an important role in inflammation. However, its role in inflammatory bowel disease is not clear. A recent study showed that Cav-1 is increased and mediates angiogenesis in dextran sodium sulphate-induced colitis, which are contradictory to our pilot findings in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. In the present study, we further clarified the role of Cav-1 in TNBS-induced colitis.