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7706736 
Journal Article 
Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill 
Reinhart, K; Kuhn, HJ; Hartog, C; Bredle, DL 
2004 
Yes 
Intensive Care Medicine
ISSN: 0342-4642
EISSN: 1432-1238 
30 
8 
1572-1578 
English 
15197435 
WOS:000223014400011 
OBJECTIVE: To compare the course of continuously measured mixed and central venous O(2) saturations in high-risk patients and to evaluate the impact of various factors that might interfere with reflection spectrophotometry.

DESIGN AND SETTING: Prospective, descriptive study in the interdisciplinary ICU of a university hospital.

PATIENTS: 32 critically ill patients with triple-lumen central vein catheters, including 29 patients requiring pulmonary artery catheterization.

INTERVENTIONS: The accuracy of fiberoptic measurements was assessed by comparison to reference co-oximeter results at regular intervals. We examined the effect on measurement accuracy of physiological variables including hematocrit, hemoglobin, pH, temperature, and the administration of various solutions via central venous catheter. Continuous parallel measurements of SvO(2) and ScvO(2) were performed in patients with each type of catheters over a total observation time of 1097 h.

RESULTS: ScvO(2) values were more accurate and stable than in vitro oximeter measurements ( r=0.96 from 150 samples, mean difference 0.15%, average drift 0.10%/day) and was not significantly affected by synchronous infusion therapy or by changes in hematocrit, hemoglobin, pH, or temperature. ScvO(2) values closely paralleled SvO(2), whether measured in vitro ( r=0.88 from 150 samples) or in vivo ( r=0.81 from 395,128 samples) but averaged about 7+/-4 saturation percentage higher. ScvO(2) changed in parallel in 90% of the 1,498 instances in which SvO(2) changed more than 5% (over an average of 43 min).

CONCLUSIONS: Continuous fiberoptic measurement of central vein O(2) saturation has potential to be a reliable and convenient tool which could rapidly warn of acute change in the oxygen supply/demand ratio of critically ill patients.