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HERO ID
7728537
Reference Type
Journal Article
Title
Acetylcholinesterase Inhibitor From Tabernaemontana pandacaqui Flowers
Author(s)
Athipornchai, A; Ketpoo, P; Saeeng, R
Year
2020
Is Peer Reviewed?
1
Journal
Natural Product Communications
ISSN:
1934-578X
Publisher
SAGE Publications Inc.
Volume
15
Issue
3
Language
English
DOI
10.1177/1934578X20911488
Web of Science Id
WOS:000525437700001
Abstract
The inhibition of acetylcholinesterase (AChE) is still considered a strategy for the treatment of Alzheimerâs disease. The aim of this study was the search for potential drugs from natural sources which can inhibit AChE. The methanol extract of fresh flowers of Tabernaemontana pandacaqui was partitioned with n-hexane and ethyl acetate. All extracts were evaluated for AChE inhibitory activity. The ethyl acetate fraction, which showed the strongest AChE inhibitory activity, was fractionated using various chromatographic techniques, leading to the isolation of 6 compounds (1-6), which were identified mainly by spectroscopic techniques; this is the first report of these compounds from T. pandacaqui flowers. Astragalin (6) was the major active constituent. The structure-AChE inhibitory activity relationship of 6 and its derivatives was studied. The results suggest that T. pandacaqui flowers and its flavonoid compounds could be potentially used for the treatment of Alzheimerâs disease. © The Author(s) 2020.
Keywords
Tabernaemontana pandacaqui; acetylcholinesterase inhibitory activity; Alzheimer's disease; astragalin; flavonoids
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