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7729686 
Journal Article 
LC-separation of derivatized DL-amino acids by aminopropylsilica-bonded Marfey's reagent and analog 
Bruckner, H; Leitenberger, M 
1996 
Yes 
Chromatographia
ISSN: 0009-5893
EISSN: 1612-1112 
FRIEDR VIEWEG SOHN VERLAG GMBH 
WIESBADEN 1 
42 
11-12 
683-689 
English 
WOS:A1996UX42600012 
Two chiral stationary phases (CSP-1 and CSP-2)) were synthesized by covalent bonding of aminopropylsilica (APS) to (a) 1-fluoro-2,4- dinitrophenyl-5-L-alanine amide (Marfey's reagent), followed by end-capping of underivatized amino groups of APS with trifluoroacetic anhydride (CSP-1), and (b) by reaction of APS with 1-fluoro-2,4-dinitrophenyl-5-L-phenylalanine tert. butyl ester, followed by cleavage of the tert. butyl ester by trifluoroacetic acid and end-capping of underivatized amino groups of APS with n-butyryl chloride (CSP-2). Both CSPs were found to be suitable for the chiral resolution of 2,4-dinitrophenyl and 3,5-dinitrobenzoyl-DL-amino acid esters by liquid chromatography using mixtures of n-hexane and iso-propanol as eluents. Racemic 2,2,2-trifluoro-1-(9-anthryl)ethanol was also resolved on CSP-2. 
column liquid chromatography; chiral stationary phase; enantiomer separation; amino acids 
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     2,​2,​2-​trifluoro-Acetic acid-​d