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7741008 
Journal Article 
Antifungal Activity and Mechanism of Major Compound Isolated from Hexane Extract of Curcuma zedoaria 
Chen, Z; Wei, Yan; Li, Xue; Peng, C; Long, Z 
2013 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
Chemical Publishing Co. 
SAHIBABAD 
25 
12 
6597-6600 
English 
WOS:000325088800025 
The main compound of hexane extract from Curcuma zedoaria was purified using bioactive-guided silica gel column chromatography and high performance liquid chromatography in this study and the structure of the main compound was identified as curcumenol by spectroscopic methods, including high resolution mass spectra (HRMS), FTIR, 1H and 13C NMR spectroscopy. It was firstly authenticated that curcumenol derived from C. zedoaria showed higher and broad-spectrum antifungal activity against fungal phytopathogens, such as Fusarium graminearum, Phoma wasabiae, Plasmodiophora brassicae and Magnaporthe grisea while their minimal inhibition concentration were 0.5 1.0, 1.0, 1.0 mg mL-1, respectively. The antifungal activity was not affected by high or low pH values (from 2-10) or under different temperatures (from 30-80 °C). Its antifungal mechanism was further investigated by comparing the ultrastructures of the experimental fungi using scanning electron microscope and transmission electron microscope and results showed that its antifungal activity was realized by means of destroying the cell-wall and influencing the nutrients circulation of the fungal phytopathogens. © 2013 Asian Journal of Chemistry. 
Curcuma zedoaria; Antifungal activity; Curcumenol; Stability; Mechanism