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7743369 
Journal Article 
Lipase-catalyzed resolution of primary alcohol containing quaternary chiral carbon 
Cheong, CS; Im, DS; Kim, J; Kim, IO 
1996 
Yes 
Biotechnology Letters
ISSN: 0141-5492
EISSN: 1573-6776 
SPRINGER 
DORDRECHT 
18 
12 
1419-1422 
English 
WOS:A1996VZ07600012 
2-Cyano-2-phenyl-1-hexanol containing chiral quaternary carbon was resolved using a lipase. Among various reaction conditions, transesterification reaction (solvent; n-hexane, lipase; Candida cylindracea) gave high selectivity(20/80). Additionally, the selectivity could be improved(13/87) when pyridine(1%) was used as an additive. The ratios of resolved alcohols were determined by GC and 1H-NMR analysis using Mosher's derivative.