US EPA

7745255 

Journal Article 

Copolyester of citric acid and 1,2,6-hexane triol as a matrix for controlled drug delivery 

Pramanick, D; Ray, TT; Bakr, MA 

1996 

Yes 

Journal of Polymer Materials
ISSN: 0970-0838 

A A BALKEMA 

ROTTERDAM 

13 

2 

173-178 

English 

WOS:A1996VA76200013 

Four samples of crosslinked copolyesters of citric acid and 1,2,6-hexane triol with different mole ratios using anhydrous FeCl3 as catalyst have been synthesized as amorphous and insoluble solids. These were characterized by IR spectra, elemental analyses, glass transition temperature (Tg) and equilibrium swellings in water, ethanol and ethylene carbonate. The copolyester sample synthesized from acid to triol mole ratio 1.05 has the maximum crosslink density and has been chosen as the matrix for the slow release of drugs. By the action of three types of bacteria, namely, S. marcescens, B. subtilis and E. coli, the copolyester has been shown to be enzymatically degradable. The drug release behavior of this biodegradable copolyester has been illustrated by incorpoating a common drug paracetamol and showing its release pattern in vitro. 

controlled drug delivery; biodegradable copolyester matrix; paracetamol; 1,2,6-hexane triol