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7745504 
Journal Article 
Pharmacological screening of Salsola baryosma 
Ahmed, S; Ashraf, M; Jabbar, A; Janbaz, KH; Khan, MS; Gilani, AH; Choudhary, MI 
2006 
Yes 
Journal of the Chemical Society of Pakistan
ISSN: 0253-5106 
CHEM SOC PAKISTAN 
KARACHI 
28 
1 
82-83 
English 
WOS:000237913100016 
The present work describes preliminary pharmacological screening of Salsola baryosma. Ethanol (80 %) extract (A) of the plant was suspended in water and sub-fractioned into n-hexane (B), EtOAc (C) and n-BuOH (D) soluble fractions. These fractions (1mg/ ml) showed 52 to 100 % phytotoxicity and showed 50 % cytotoxicity as determined by brine shrimp lethality assay. DPPH radical scavenging activity of fraction 'C' was 77% whilst other fractions had antioxidant activity below 57 %. When fraction 'A' was tested for antispasmodic activity, spontaneous contractions were recorded at 0.3-3.0 mg/ ml concentration in isolated rabbit jejunum preparations. It also inhibited K+ induced contractions to 70 % at 1-5 mg/ ml level, suggesting a calcium channel blockade activity.