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7752770 
Journal Article 
Construction of 3-Azabicyclo[3.1.0]hexane Backbone by the Reaction of Allenes with Allylamines via Tandem Michael Addition and Copper-Mediated Oxidative Carbanion Cyclization 
Xu, Hui; Han, T; Luo, X; Deng, W 
2021 
Yes 
Chinese Journal of Chemistry
ISSN: 1001-604X 
Shanghai Institute of Organic Chemistry 
39 
3 
666-670 
English 
WOS:000640183200001 
A facile synthetic method for the construction of 3-azabicyclo[3.1.0]hexane in the presence of copper catalyst system was developed. The reaction proceeds through Michael addition of allylamines with allenes followed by copper-mediated intramolecular oxidative carbanion 5-exo-trig radical cyclization, affording potential biologically active 3-azabicyclo[3.1.0]hexane derivatives in moderate to high yields (42%—85%). © 2021 SIOC, CAS, Shanghai and Wiley-VCH GmbH 
Oxidative coupling; Allenes; Allylamine; 3-Azabicyclo[3; 1; 0]hexane; Miachel addition