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7752840 
Journal Article 
Synthesis and crystal structure of 3,3 '-(hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin), a new inducer of differentiation 
Song, XZ; Liu, G; Shen, LC; Zhang, SW 
2002 
Yes 
Chinese Journal of Structural Chemistry
ISSN: 0254-5861 
21 
5 
481-484 
English 
WOS:000178238900005 
The title compound (C20OH30N4O 6, Mr = 422.48) was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in the triclinic system, space group P1 with cell parameters: a = 8.330(2), b = 8.468(2), c = 16.017(3) Å, α = 97.30(3), β = 92.33(3), γ = 103.94(3)°, V = 1084.7(4) Å3, Dc = 1.294 g/cm3, Z = 2, F(000) = 452 and μ = 0.096 mm-1. The structure was refined to R = 0.0483 for 3732 observed reflections with I> 2σ(I) and wR = 0.1335 for 4828 unique reflections. The hydantoin rings are planar and the two ring planes of one molecule are paralleled to each other. 
HMBA; anticancer; activity; cancer cell inducer of differentiation; crystal structure