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7755416 
Journal Article 
Determination, Correlation, and Application of Sodium L-Ascorbate Solubility in Nine Pure Solvents and Two Binary Solvents at Temperatures from 278.15 to 323.15 K 
Zhang, Hui; Liu, Z; Huang, X; Zhang, Qi 
2018 
Yes 
Journal of Chemical and Engineering Data
ISSN: 0021-9568
EISSN: 1520-5134 
American Chemical Society 
63 
1 
233-245 
English 
WOS:000422813400027 
The solubility data of sodium l-ascorbate in water, methanol, ethanol, acetone, chloroform, ethyl acetate, isopropyl alcohol, isobutyl alcohol, n-hexane, water-methanol mixture and water-ethanol mixture have been determined in the temperatures range of 278.15-323.15 K by a static analytic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation, CNIBS/R-K model, and Jouyban-Acree model. On the basis of the solubility data, a novel model-free design approach (semisupersaturation control, SSSC) for combined cooling and antisolvent crystallization (CCAC) processes has been proposed and evaluated for sodium l-ascorbate in a methanol-water mixture. This approach can be easily implemented without complicated online monitors. Sodium l-ascorbate crystals with large and uniform morphology were obtained using the CCAC process, which was designed by the SSSC approach. © 2017 American Chemical Society.