Health & Environmental Research Online (HERO)


Print Feedback Export to File
7757402 
Journal Article 
Synthesis, Structural Chemistry, and Biological Studies on Various Divalent Copper Chelates of Novel Ligands Derived from Food Preservative, Dehydroacetic Acid, with Anilines 
Abdel-Salam, AH 
2019 
Yes 
Journal of the Chemical Society of Pakistan
ISSN: 0253-5106 
Chemical Society of Pakistan 
41 
6 
1055-1064 
English 
WOS:000504338600017 
Various six coordinated copper(II) complexes of novel (E)-4-hydroxy-6-methyl-3-(1-(ptolylimino) ethyl-2H-pyran-2-one (HL1) and (E)-3-(1-(4-chlorophenylimino) ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (HL2) derived from 3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one (dehydroacetic acid, DHA) and aniline derivatives (p-chloroaniline and p-toluidine) were fabricated. The coordination mode of Schiff base donor atoms with copper ions was well investigated by thermal and elemental analyses, FTIR, UV-vis, 1H, 13C-NMR spectral tools and measurements of magnetic susceptibility as well as molar conductance at ambient temperature. The novel neutral bidentate Schiff base ligands (HL1 and HL2) linked to Cu(II) cation via the azomethine-N and hydroxyl-O atoms and to acetate and nitrate anions in bidentate bridging mode to form polymeric octahedral complexes. The thermal study showed the stepwise removal of water of hydration and anions and decomposition of these chelates. The decomposition products were examined and the relative thermal stabilities of these chelates were evaluated. Different parameters of activation were derived from the thermal curves by Coats–Redfern methodology. The degradation steps of the metal complexes had positive free energy values indicating their non-spontaneous nature. The antifungal and antibacterial activities of all investigated compounds were also studied. The magnetic susceptibility measurements and conductance data were investigated and provided evidence for the non-electrolytic character of the complexes. © 2019 Chemical Society of Pakistan. All rights reserved. 
Anilines Schiff bases; Dehydroacetic acid; Polymeric copper chelates; Biological Activity