Health & Environmental Research Online (HERO)


Print Feedback Export to File
781995 
Journal Article 
Factors that impact susceptibility to fiber-induced health effects 
Below, JE; Cox, NJ; Fukagawa, NK; Hirvonen, A; Testa, JR 
2011 
Yes 
Journal of Toxicology and Environmental Health, Part B: Critical Reviews
ISSN: 1093-7404
EISSN: 1521-6950 
14 
1-4 
246-266 
English 
Asbestos and related fibers are associated with a number of adverse health effects, including malignant mesothelioma (MM), an aggressive cancer that generally develops in the surface serosal cells of the pleural, pericardial, and peritoneal cavities. Although approximately 80% of individuals with MM are exposed to asbestos, fewer than 5% of asbestos workers develop MM. In addition to asbestos, other mineralogical, environmental, genetic, and possibly viral factors might contribute to MM susceptibility. Given this complex etiology of MM, understanding susceptibility to MM needs to be a priority for investigators in order to reduce exposure of those most at risk to known environmental carcinogens. In this review, the current body of literature related to fiber-associated disease susceptibility including age, sex, nutrition, genetics, asbestos, and other mineral exposure is addressed with a focus on MM, and critical areas for further study are recommended. 
IRIS
• Asbestos