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HERO ID
782758
Reference Type
Journal Article
Title
Tetrahydrofuran: two-generation reproduction toxicity in Wistar rats by continuous administration in the drinking water
Author(s)
Hellwig, J; Gembardt, C; Jasti, S
Year
2002
Is Peer Reviewed?
Yes
Journal
Food and Chemical Toxicology
ISSN:
0278-6915
EISSN:
1873-6351
Location
England
Volume
40
Issue
10
Page Numbers
1515-1523
Language
English
PMID
12387317
DOI
10.1016/S0278-6915(02)00089-3
Web of Science Id
WOS:000177218200022
URL
http://www.sciencedirect.com/science/article/pii/S0278691502000893
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Abstract
In a two-generation reproduction toxicity study, 25 male and 25 female Wistar rats per dose group and generation were exposed continuously to tetrahydrofuran in the drinking water for at least 70 days prior to and during mating, gestation, parturition and lactation to weaning, at concentrations of 0, 1000, 3000 or 9000 ppm (approximately 100, 300 and 700 mg/kg/day in males and females premating, 100, 300 and 800 mg/kg/day in females during gestation, and 200, 500 and 1300 mg/kg/day in females during lactation) through two successive generations. In both generations and sexes, water consumption was dose-relatedly reduced at all doses; food consumption and body weight were reduced at 9000 ppm. Necropsy kidney weights were increased in 9000 ppm F0 males. Pup body weight gain during lactation was reduced in both generations (F1 and F2 pups) and eye opening delayed in the first generation (F1 pups) at 9000 ppm; there were no treatment-related malformations. The NOAEL of tetrahydrofuran in drinking water is 9000 ppm for parental fertility and reproductive performance, and 3000 ppm for systemic parental and developmental toxicity.
Keywords
Rats; Furans; Eating; Lactation; Rats, Wistar; Index Medicus; Organ Size; Reproduction; Female; Body Weight; Pregnancy; Animals; Drinking; Male; Weight Gain; Kidney
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