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HERO ID
7828261
Reference Type
Journal Article
Subtype
Review
Title
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
Author(s)
Moreira, PI; Siedlak, SL; Aliev, G; Zhu, X; Cash, AD; Smith, MA; Perry, G
Year
2005
Is Peer Reviewed?
Yes
Journal
Journal of Neural Transmission
ISSN:
0300-9564
EISSN:
1435-1463
Volume
112
Issue
7
Page Numbers
921-932
Language
English
PMID
15583960
DOI
10.1007/s00702-004-0242-8
Web of Science Id
WOS:000229624600007
Abstract
Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disorders is the alteration of iron and copper homeostasis. Data from the literature support the involvement of metal homeostasis in mitochondrial dysfunction, protein alterations and nucleic acid damage which are relevant in brain function and consequently, in the development of neurodegenerative disorders. Although alterations in transition metal homeostasis, redox activity, and localization are well documented, it must be determined how alterations of specific copper- and iron-containing metalloenzymes are also involved in Alzheimer disease. The clarification of these phenomena can open a new window for understanding the mechanisms underlying neurodegeneration and, consequently, for the development of new therapeutic strategies such as gene therapy and new pharmaceutical formulations with antioxidant and chelating properties.
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