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783127 
Journal Article 
Effects of intraperitoneally injected acrylonitrile on liver, kidney and brain 
Zitting, A; Tenhunen, R; Savolainen, H 
1981 
Yes 
Acta Pharmacologica et Toxicologica
ISSN: 0001-6683 
49 
5 
412-415 
English 
7345882 
WOS:A1981NB36300011 
The considerable toxic potential of acrylonitrile, a valuable intermediate used in the manufacture of acrylonitrile-butadiene-styrene copolymer and acrylic fibers, has been widely acknowledged. Ip. injection of Chinese hamsters with acrylonitrile (30 mg/kg) decreased the glutathione content of liver and brain 4 h later. Twenty-four h after the injection, liver and kidney weights were increased; cerebral and renal glutathione concentrations were also increased. Cerebral succinate dehydrogenase and cytochrome oxidase activities were decreased as were liver and kidney ethoxycoumarin deethylase activity and liver microsomal cytochrome P-450 content. These biochemical effects may have been caused by acrylonitrile metabolites, glycidonitrile and CN-, the hypoxic consequences associated with the latter being largely abolished after 72 h. 
Acrylonitrile; glycidonitrile; cyanide; glutathione; cytochrome oxidase; hamsters