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7847046 
Journal Article 
Review 
Degradation of xenobiotic compounds by lignin-degrading white-rot fungi: enzymology and mechanisms involved 
Christian, V; Shrivastava, R; Shukla, D; Modi, HA; Vyas, BR 
2005 
Yes 
Indian Journal of Experimental Biology
ISSN: 0019-5189
EISSN: 0975-1009 
43 
4 
301-312 
English 
15875713 
White-rot fungi (WRF) are ubiquitous in nature with their natural ability to compete and survive. WRF are the only organisms known to have the ability to degrade and mineralize recalcitrant plant polymer lignin. Their potential to degrade second most abundant carbon reserve material lignin on the earth make them important link in global carbon cycle. WRF degrade lignin by its unique ligninolytic enzymatic machinery including lignin peroxidase, manganese peroxidase, laccase, cellobiose dehydrogenase, H2O2-generating enzymes, etc. The ligninolytic enzymes system is non-specific, extracellular and free radical based that allows them to degrade structurally diverse range of xenobiotic compounds. Lignin peroxidase and manganese peroxidase carry out direct and indirect oxidation as well as reduction of xenobiotic compounds. Indirect reactions involved redox mediators such as veratryl alcohol and Mn2+. Reduction reactions are carried out by carboxyl, superoxide and semiquinone radicals, etc. Methylation is used as detoxification mechanism by WRF. Highly oxidized chemicals are reduced by transmembrane redox potential. Degradation of a number of environmental pollutants by ligninolytic system of white rot fungi is described in the present review. 
Basidiomycota/enzymology/growth & development; Biodegradation, Environmental; Lignin/metabolism; Xenobiotics/chemistry