Health & Environmental Research Online (HERO)


Print Feedback Export to File
7847381 
Journal Article 
[Evaluation on biocompatibility of Ti-Fe-Mo-Mn-Nb-Zr alloy] 
Yu, S; Zhang, X; Lao, F; Zhang, X; He, Z; Liu, Y; Liu, Z 
2004 
0 
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi / Journal of Biomedical Engineering
ISSN: 1001-5515 
21 
2 
200-204 
Chinese 
15143539 
In this study, the general toxicity tests including acute toxicity test, haemolysis test, MTT assay of Ti-Fe-Mo-Mn-Nb-Zr alloys were carried out. The morphology of these cells was also observed under phase-contrast microscope. By using X-ray photoelectron spectroscopy(XPS), the kind and mol% of element in surface film were studied. The kind and concentration of element in dipping fluid were investigated by ICP atomic emission spectrometry. The results showed the primary component is TiO2 in surface film. The dipping fluid of Ti-Fe-Mo-Mn-Nb-Zr alloys contains Fe 0.2-1.07 mg/l and Mn 0.16-0.5 mg/l; such dental materials are beneficial to health. No cytotoxic effect was disclosed by in vitro and in vivo tests. The level of cytotoxicity was grade 0 and 1; the haemolysis degree was 0.558%-0.642%, i.e. less than 5%. The cells growing in the extract showed normal morphology. These data indicate that Ti-Fe-Mo-Mn-Nb-Zr alloy, as a dental material, has good biocompatibility. 
Animals; Biocompatible Materials/chemistry/toxicity; Dental Alloys/toxicity; Iron/toxicity; Manganese; Molybdenum/toxicity; Niobium/toxicity; Osmotic Fragility; Rabbits; Random Allocation; Spectrometry, X-Ray Emission; Titanium/toxicity; Zirconium/toxicity