US EPA

7852373 

Journal Article 

Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model 

Choi, EJ; Lee, HJ; Kim, WJ; Han, KI; Iwasa, M; Kobayashi, K; Debnath, T; Tang, Y; Kwak, YS; Yoon, JH; Kim, EK 

2019 

1 

PLoS ONE
EISSN: 1932-6203 

14 

2 

e0210854 

English 

30818368 

10.1371/journal.pone.0210854 

WOS:000460371500010 

Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD.