Nitration of tert-butyloxycarbonylated aniline and 1,3,5-triaminobenzene by acetyl nitrate | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

7855481

Reference Type

Journal Article

Title

Nitration of tert-butyloxycarbonylated aniline and 1,3,5-triaminobenzene by acetyl nitrate

Author(s)

Davis, MC; Groshens, TJ

Year

2012

Is Peer Reviewed?

Journal

Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

Location

OXFORD

Volume

Issue

Page Numbers

4154-4155

Language

English

DOI

10.1016/j.tetlet.2012.05.139

Web of Science Id

WOS:000306766200030

URL

http://://WOS:000306766200030
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Abstract

Acetyl nitrate was found to be an effective reagent for aromatic mono- and dinitration of Boc-protected aminobenzenes. The method was used in a new synthesis of 1,3,5-triamino-2,4-dinitrobenzene in two steps with 63% yield. © 2012 Elsevier Ltd. All rights reserved.

Keywords

Aromatic nitration; Acetyl nitrate; Aniline; Boc-protection