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7856912 
Journal Article 
Hexafluoroisopropanol as a Low-Boiling Extraction Solvent for 5-Hydroxymethylfurfural Production 
Weingart, E; Teevs, L; Krieg, R; Pruesse, Ulf 
2018 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
6 
2 
432-440 
English 
WOS:000424795100029 
In this study, we show that the fluorous alcohol hexafluoroisopropanol (HFIP) can act as a superior solvent for the in situ extraction of 5-hydroxymethylfurfural (HMF) from an aqueous reaction system. HFIP has a far higher partition coefficient for HMF than common extraction solvents such as methyl isobutyl ketone (MIBK) and n-butanol and has a significantly lower boiling point of 58–59 °C. In a system containing fructose, HCl as the catalyst, and HFIP as the extraction solvent, a high HMF yield of 89 % is achieved, which is far better than the HMF yields in common MIBK/butanol extraction systems. HFIP extracts HMF from the reaction phase without extraction of the fructose educt. In addition, the aqueous catalyst phase can be reused. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 
biofuels; carbohydrates; dehydration; green chemistry; solvent extraction