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7890565 
Journal Article 
Allergic contact dermatitis to Biseptine (R) in a child 
Kefala, K; Ponvert, C 
2020 
1 
Revue Francaise d'Allergologie
ISSN: 1877-0320 
Elsevier Masson s.r.l. 
60 
8 
614-618 
English; French 
WOS:000594400200010 
Allergies to topical antiseptics are relatively rare. Most cases are local reactions (contact dermatitis), but the number of cases related to immediate-type hypersensitivity increases continuously, especially in adults. Cases of immediate-type and non immediate-type allergy to topical antiseptics have been reported in children. We report a case of Biseptine®-induced contact dermatitis in a 3,5-year-old-boy who tolerated neonatal ombilical treatment with this antiseptic, but developed the first reaction at age 4 months and several reactions to subsequent exposures to chlorhexidine. The diagnosis was confirmed by positive responses in non immediate-reading skin tests with chlorhexidine. Patch-tests were also positive with benzalkonium chloride and benzylic alcohol, the two other components of Biseptine®. This case confirms that: (1) although they are rare, contact dermatitis induced by chlorhexidine can occur in children and may be associated with cosensitizations to benzalkonium chloride and benzylic alcohol; (2) sensitizations can occur neonatally and induce reactions at a very young age; (3) this dermatosis is frequently unrecognized by general practitioners and paediatricians, and often diagnosed as infectious reactions; (4) diagnosis is based on standardized non immediate-reading skin tests, with a good diagnostic value. © 2020 Elsevier Masson SAS 
Contact allergy; Chlorhexidin; Child; Patch-test; Diagnosis