Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh(II)/Zr(IV)-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7898017

Reference Type

Journal Article

Title

Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh(II)/Zr(IV)-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes

Author(s)

Zhang, X; Huang, H; Guo, X; Guan, X; Yang, L; Hu, W

Year

2008

Is Peer Reviewed?

Yes

Journal

Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773

Volume

Issue

Page Numbers

6647-6649

Language

English

PMID

18646030

DOI

10.1002/anie.200801510

Web of Science Id

WOS:000258706600024

Abstract

(Chemical Equation Presented) The right combination: A catalytic asymmetric multicomponent reaction has been developed in which two stereogenic carbon centers are constructed in a single step (see scheme; erythro/threo 90:10, up to 80% yield, 98% ee).This type of enantioselective three-component reaction generates Î±,Î²-dihydroxy acid derivatives in good yields and with excellent enantioselectivities. Bn =benzyl. Â© 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

Asymmetric catalysis; Diazo compounds; Lewis acids; Multicomponent reaction; Ylides