Capillary electrophoretic analysis of ethylene dicysteine, a precursor of the radiopharmaceutical 99mTc ethylene dicysteine | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7902646

Reference Type

Journal Article

Title

Capillary electrophoretic analysis of ethylene dicysteine, a precursor of the radiopharmaceutical 99mTc ethylene dicysteine

Author(s)

Van Schepdael, A; Verbeke, K; Van Nerom, C; Hoogmartens, J; Verbruggen, A

Year

1997

Is Peer Reviewed?

Yes

Journal

Journal of Chromatography B: Biomedical Sciences and Applications
ISSN: 1387-2273
EISSN: 1878-5603

Volume

697

Issue

1-2

Page Numbers

251-254

Language

English

PMID

9342676

DOI

10.1016/s0378-4347(97)00027-3

Abstract

L,L-Ethylene dicysteine (EC) is a ligand used in nuclear medicine for the preparation of 99mTc-L,L-EC, a tracer agent for renal function studies. A capillary zone electrophoretic method is described which allows us to monitor the purity of ethylene dicysteine, for which no other suitable method has been reported to date. A fused-silica capillary (L = 70 cm, l = 62 cm, 75 microns i.d.) was used with 10 mM sodium tetraborate, pH 10.0, as the background electrolyte. The voltage applied was 20 kV and the temperature was 25 degrees C. Benzyl alcohol served as the internal standard. The limit of detection was 0.07% and the limit of quantitation was 0.15%.