US EPA

7905095 

Journal Article 

Areca catechu L. extract. II. Effects on inflammation and melanogenesis 

Lee, KK; Do Choi, J 

1998 

1 

Journal of Cosmetic Science
ISSN: 1525-7886
EISSN: 2689-5153 

49 

6 

351-359 

English 

WOS:000079311800002 

Ethanolic extract (CC-516) from Areca catechu L. was prepared, and its various biological activities were evaluated. CC-516 showed potent anti-oxidative, free-radical scavenging, and anti-hyaluronidase activity. The anti-oxidative effect of CC-516 (IC50: 45.4 μg/ml) was lower than that of butylated hydroxytoluene (IC50: 5 μg/ml), but similar to that of tocopherol and higher than that of ascorbic acid. Especially, CC-516 exhibited relatively high free-radical scavenging activity (IC50: 10.2 μg/ml) compared to that of the control. CC-516 effectively inhibited hyaluronidase activity (IC50 416 μg/ml) and showed inhibition in vivo on delayed hypersensitivity as well as croton-oil-induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 is shown by the inhibition of mushroom tyrosinase activity with an IC50 value of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory activity/anti-melanogenesis, and can be used as a new agent for cosmetics.