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7908706 
Journal Article 
Stability-indicating LC method for the simultaneous determination of methyl paraben, propyl paraben, butylated hydroxytoluene and alpha-tocopherol contents in marijuana capsules 
Dongala, T; Palakurthi, AK 
2020 
Yes 
Journal of the Iranian Chemical Society
ISSN: 1735-207X
EISSN: 1735-2428 
Springer 
17 
3 
631-638 
English 
WOS:000492552700001 
Abstract: The current study is a simple liquid chromatographic method developed and validated for the simultaneous determination of methyl paraben, propyl paraben, butylated hydroxytoluene and alpha-tocopherol in marijuana (delta-8-tetra hydro cannabinol (or) dronabinol) soft gelatin capsules by using high-performance liquid chromatographic technique. The chromatographic separation was achieved on a Waters Xterra RP18 (150 × 4.6)-mm 5-µm column with a mobile phase contained gradient mixtures, which constitutes of purified water and acetonitrile in the ratio of 700:300 (Port-A) and acetonitrile (Port-B). The optimized flow rate of 2.0 mL/min and UV detection was made at 210 nm and column temperature of 40 °C. The resolution among MP, PP, BHT and ATP was found to be > 4. The optimized method was validated as per the guidelines prescribed by the international conference on harmonization. Regression analysis confers a correlation coefficient higher than 0.999 for MP, PP, BHT and ATP peaks. The % RSD for the interday and intraday precisions for MP, PP, BHT and ATP was estimated and found to be < 5.0. The proposed HPLC method could be suitable for the estimation of these drugs in different types of pharmaceutical drug products. Graphic abstract: Schematic diagram of the procedure for the simultaneous determination of MP, PP, BHT and ATP contents in marijuana capsules[Figure not available: see fulltext.]. © 2019, Iranian Chemical Society. 
RP-HPLC; Methyl paraben; Propyl paraben; Butylated hydroxytoluene; Alpha-tocopherol; Marijuana soft capsules